![]() 2012Įffects of Dietary Genistein on Plasma and Liver Lipids, Hepatic Gene Expression, and Plasma Metabolic Profiles of Hamsters with Diet-Induced Hyperlipidemia. Tan, Zhijing,Hu, Yuanlei,Lin, Zhongping,Liu, Rongrong. Production of isoflavone genistein in transgenic IFS tobacco roots and its role in stimulating the development of arbuscular mycorrhiza. Genistein Increases Progesterone Secretion By E.levating Related Enzymes In C hicken Granulosa Cells. Jiang, Wenbo,Xia, Yaying,Shen, Guoan,Pang, Yongzhen,Pang, Yongzhen,Liu, Jinyue,Liu, Jinyue,Liu, Jinyue,Wang, Xuemin. Genistein-Specific G6Dt Gene For The I.nducible Production Of Wighteone I n Lotus Japonicus. Jingwei Lv,Cong Lu,Ning Jiang,Haixia Wang,Hong Huang,Ying Chen,Yujiao Li,Xinmin Liu. Protective effect of ginsenoside Rh2 on scopolamine‐induced memory deficits through regulation of cholinergic transmission, oxidative stress and the Marin-Saez, Jesus,Romero-Gonzalez, Roberto,Garrido Frenich, Antonia,Chen, Hongping,Chen, Hongping. Simultaneous Determination Of Atropine And S.copolamine In Buckwheat And R elated Products Using Modified Quechers And Liquid Chromatography Tandem Mass Spectrometry. ![]() Lu, Cong,Lv, Jingwei,Wang, Yan,Wang, Fengzhong,Chen, Shanguang,Wang, Qiong,Fan, Bei,Li, Yinghui,Jiang, Ning,Lu, Cong,Liu, Xinmin,Dong, Liming. Neuroprotective Effects Of 20(S)-Protopanaxatriol (Ppt) O.n Scopolamine-Induced Cognitive Deficits I n Mice. Lu, Cong,Lu, Cong,Jiang, Ning,Liu, Xinmin,Lv, Jingwei,Zhang, Lijing,Wang, Yan,Fan, Bei,Wang, Donghui,Wang, Fengzhong. Neuroprotective Effects Of Soy Isoflavones O.n Scopolamine-Induced Amnesia In M ice. Lu, Cong,Liu, Xinmin,Liu, Xinmin,Lv, Jingwei,Dong, Liming,Wang, Fengzhong,Fan, Bei,Wang, Yan,Lu, Cong. Taken together, these results for the first time found that GE exerts cognitive-improving effects in Scop-induced amnesia and suggested it may be a potential candidate compound for the treatment of some neurodegenerative diseases such as Alzheimer's Disease (AD).Ģ0(S)-Protopanaxadiol (Ppd) Alleviates Scopolamine-Induced Memory I.mpairment Via Regulation Of C holinergic And Antioxidant Systems, And Expression Of Egr-1, C-Fos And C-Jun In Mice. Furthermore, GE was found to significantly upregulate the expression levels of p-ERK, p-CREB and BDNF proteins in the hippocampus of Scop-treated mice. Additionally, GE remarkably promoted the cholinergic neurotransmission and protected against the oxidative stress damage in the hippocampus of Scop-treated mice, as indicated by decreasing AChE activity, elevating ChAT activity and Ach level, increasing SOD activity, lowering the level of MDA and increasing GSH content. ![]() ![]() The results showed that GE administration significantly improved the cognitive performance of Scop-treated mice in OLR and Morris water maze tests, exerting the memory-enhancing effects. After the behavioral tests, biochemical parameter assay and western blot analysis were used to examine the underlying mechanisms of its action. Thereafter, mice were daily injected with Scop (0.75 mg/kg) intraperitoneally to induce memory deficits and subjected to the cognitive behavioral tests including the Object Location Recognition (OLR) experiment and Morris Water Maze (MWM) task. After the pretreatment, the open field test was conducted to assess the effect of GE on the locomotor activity of mice. The mice were orally pretreated with either GE (10, 20, and 40 mg/kg) or donepezil (1.60 mg/kg) for 14 days. Therefore, the present study was carried out to investigate the beneficial effects and potential mechanism of GE against Scop-induced deficits in mice. However, there is no report about the effects of GE on Scop-induced amnesia in mice. The animal model of scopolamine (Scop)-induced amnesia is widely used to study underlying mechanisms and treatment of cognitive impairment in neurodegenerative diseases. In addition, both clinical and preclinical studies have recently suggested GE a potential neuroprotective and memory-enhancing drug against neurodegenerative diseases. Genistein (GE) was reported to exert a wide spectrum of biological activities, including antioxidant, anti-inflammatory, anti-mutagenic, anticancer, and cardio-protective effects. Genistein scopolamine memory deficits cholinergic neurotransmission antioxidant system the ERK/CREB/BDNF signaling Fan, Bei Lu, Cong Liu, Xinmin Zhang, Lijing Wang, Donghui Xu, Teng Wang, Fengzhong Li, Qi Wang, Yan
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